World Diabetes Day: Can diabetes medicines help you lose weight?

Approximately 74 million people live with diabetes in India. With the rising rates of obesity, the prevalence of diabetes is also expected to further rise in India. It is well known that obesity is one of the strongest risk factors for type 2 diabetes. With significant weight loss, remission of diabetes has also been shown to occur in a large number of cases. Till now, however, treatment for obesity and diabetes had to be done independently from each other. Indeed, one of the problems with older anti diabetic medicines like insulin, sulfonylureas and pioglitazone is the weight gain which accompanies them. Hence, while the sugar levels usually get under control, one of the unwanted side effects of these medicines was weight gain.

Let’s understand the effects of diabetes medicines on weight loss!

Do diabetes medicines reduce the risk of obesity?

There are some medicines which are known to be weight neutral, for instance metformin and DPP4 inhibitors. More recently, however, two groups of agents, the SGLT2 drugs and the GLP1 receptor agonists (GLP1RA’s) developed to control diabetes have been found effective in helping patients lose weight.

diabetes drugs
Do diabetes drugs work for weight loss? Image Courtesy: Shutterstock

While the weight loss with SGLT2 groups is modest, the GLP1RA’s is quite remarkable. Indeed, the latter group of drugs have been approved in some countries as weight loss agents. The problem with the GLP1RA is that they were mostly injectables. Hence, many people were not very keen to start using them. With the development of oral semaglutide, that problem was solved. Oral semaglutide is indeed the first ‘peptide in a pill’.

The GLP1 receptor analogs have additional benefits. Apart from weight loss and blood sugar control, they are also cardio-protective and have been shown to protect against atherosclerotic cardiovascular disease.

Benefits of diabetes drugs go beyond the basics

The SGLT2 drugs also have multiple other benefits apart from blood sugar control and weight reduction. Most importantly, they prevent heart failure. Cardiologists now use this drug as the first line in the treatment of heart failure, even in those without diabetes. SGLT2 drugs also have a kidney protection effect. Hence, nephrologists have started using these drugs to protect the kidney even in those without diabetes.

diabetes medicines
Can diabetes medicines help you lose weight? Let’s find out. Image Courtesy: Shutterstock

The SGLT2 drugs and the GLP1 receptor analogs can be used along with other oral antidiabetic drugs, as well as with insulin. Thus, the treatment of diabetes has come a long way with the introduction of these newer agents. Some of the SGLT2 agents, for example, apagliflozin are now available in generic form. This has made the drug more affordable and therefore available to a larger section of people living with diabetes in India.

(Disclaimer: The views and opinions expressed in the article are of the writer.)

Source link

Leave a Reply

Your email address will not be published.

Previous post Sparkling like a jewel! Tiffany Trump poses up with sister Ivanka moments before her wedding
Next post ‘It’s so scary’: Mother remains traumatized a year after baby’s RSV diagnosis
How Miles Teller Totally Broke Royal Protocol Meeting Prince William and Kate Middleton Mila Kunis Reveals Why She and Ashton Kutcher Don’t Close Bathroom Doors at Home With Kids Khloe Kardashian and Tristan Thompson Were Engaged for 9 Months Before Paternity Lawsuit Selena Gomez Speaks Out About Kindness After Hailey Bieber’s Tell All Interview Shane Warne’s child, Jackson, shares recordings of ‘harmful ladies despising’ powerhouse Andrew Tate: ‘I really do concur with a couple of the things he says’ Kate and William to greet Americans ‘sleeping on the streets’ amid US visit ‘He said “take your bra off”… I was 15’: Supermodel Kate Moss reveals in unflinching detail how she fled a photoshoot in tears after being targeted by fashion industry predator as a teenager How to get early access to the MultiVersus open beta – usnewspress Gunman kills 3 people in Indiana mall shooting, police say Top 10 sizzling sex secrets to Spice Up Your Sex Life Stellantis Announces Termination of Jeep Venture With China’s GAC Memphis police thwart potential mass shooting at arena: Officials 4 dead after argument between 2 groups leads to shooting at north Harris County apartment complex, sheriff says US soprano, offended by blackface, pulls out of Italy opera 10 Top Romantic Getaways in New Jersey Ricky Martin’s Attorney Says Allegations of a Sexual Relationship with His Nephew Are ‘Untrue’ 8 Best Semiconductor Stocks To Buy Amid a Global Chip Shortage : USA Le’Veon Bell Reflects on Lost Season With Steelers in Retirement Post Updates on Tiger Woods from Round 1 of The Open PETE ALONSOI’M DEALING W/ ‘PRETTY BAD PTSD’… Over March Car Crash